The difference between a glove box with a purification system and one without

A glove box with a purification system actively removes and controls contaminants like moisture and oxygen, maintaining a highly controlled and ultra-low contamination environment, essential for handling sensitive materials. In contrast, a glove box without a purification system lacks active purification, relying on the initial sealed atmosphere, which can retain trace contaminants. This makes purified glove boxes more suitable for applications requiring stringent atmospheric control, whereas non-purified ones are adequate for less sensitive tasks. Here’s a detailed comparison:

Glove Box Without Purification System


  1. Basic Containment: Provides a sealed environment to protect materials from the external atmosphere and vice versa.
  2. Simple Structure: Typically includes gloves for manipulation, a viewing window, and possibly basic airlocks for introducing or removing materials.
  3. No Active Purification: The internal atmosphere is not actively filtered or purified. Once sealed, the internal air remains largely unchanged unless manually altered.
  4. Applications: Suitable for handling materials that are not highly sensitive to moisture or oxygen, such as certain biological samples, chemicals, or non-reactive substances.


  1. Contamination Risk: Trace amounts of moisture, oxygen, and other contaminants present in the initial environment can affect sensitive materials.
  2. Limited Use Cases: Not ideal for materials that require a highly controlled, low-moisture, or low-oxygen environment.

Glove Box With Purification System


  1. Advanced Containment: Provides a highly controlled environment with continuous monitoring and adjustment of internal atmosphere.
  2. Gas Purification:
    • Moisture Removal: Utilizes desiccants or molecular sieves to absorb water vapor.
    • Oxygen Removal: Employs catalysts or reactive materials to capture and remove oxygen.
  3. Real-time Monitoring: Equipped with sensors to constantly monitor the levels of moisture and oxygen, ensuring they remain at desired low levels.
  4. Regeneration System: Includes mechanisms to regenerate purification agents, maintaining their effectiveness over time.
  5. Controlled Entry: Features sophisticated airlocks or antechambers that allow materials to be introduced or removed without compromising the internal atmosphere.


  1. Sensitive Material Handling: Ideal for working with substances that are highly sensitive to moisture and oxygen, such as certain pharmaceuticals, semiconductors, and reactive chemicals.
  2. Research and Development: Used in advanced scientific research where maintaining a contamination-free environment is crucial.


  1. High Purity Environment: Maintains an ultra-low contamination environment, ensuring the integrity of sensitive materials.
  2. Versatile Use: Suitable for a broader range of applications, especially in fields requiring stringent atmospheric control.

Summary of Differences

  1. Atmospheric Control:

    • Without Purification: The internal atmosphere remains largely unchanged, with potential contamination from moisture and oxygen.
    • With Purification: Active purification maintains very low levels of contaminants, providing a highly controlled environment.
  2. Complexity and Cost:

    • Without Purification: Simpler and less expensive due to the absence of purification systems and monitoring equipment.
    • With Purification: More complex and costly due to the inclusion of gas purification, monitoring systems, and regeneration mechanisms.
  3. Suitability:

    • Without Purification: Suitable for less sensitive applications where minor contamination is not critical.
    • With Purification: Essential for applications involving highly sensitive materials requiring stringent control over moisture and oxygen levels.

By maintaining a clean and controlled atmosphere, glove boxes with purification systems are essential for industries and research areas where even trace levels of contaminants can significantly impact the outcomes. 

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